Anti-PPP1R3B Antilichaam Picoband® 31.0550 Vervoeging

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.

One cut domain family member 2; Hepatocyte nuclear factor 6-beta; HNF-6-beta; One cut homeobox 2; Transcription factor ONECUT-2; OC-2; ONECUT2; HNF6B

PPP1R3B

79660

Q86XI6

Human

No cross-reactivity with other proteins.

E.coli-derived human PPP1R3B recombinant protein (Position: M1-Y285) .

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Flow Cytometry

Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Immunogen affinity purified.

Liquid

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

1. Doherty, M. J., Moorhead, G., Morrice, N., Cohen, P., Cohen, P. T. W. Amino acid sequence and expression of hepatic glycogen-binding (G-L) -subunit of protein phosphatase-1. FEBS Lett. 375: 294-298, 1995. 2. Dunn, J. S., Mlynarski, W. M., Pezzoles, M. G., Borowiec, M., Powers, C., Krolewski, A. S., Doria, A. Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. Ann. Hum. Genet. 70: 587-593, 2006. 3. Munro, S., Cuthbertson, D. J. R., Cunningham, J., Sales, M., Cohen, P. T. W. Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G-L of liver. Diabetes 51: 591-598, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

One cut homeobox 2

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.