Anti-PRDM4 Antibody Picoband® 31.0550 Vervoeging

The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF) . This gene is located in a chromosomal region that is thought to contain tumor suppressor genes.

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

PRDM4

11108

Q9UKN5

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PRDM4 recombinant protein (Position: E87-R405) .

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Flow Cytometry

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Immunogen affinity purified.

Liquid

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

1. Briknarova, K., Atwater, D. Z., Glicken, J. M., Maynard, S. J., Ness, T. E. The PR/SET domain in PRDM4 is preceded by a zinc knuckle. Proteins 79: 2341-2345, 2011. 2. Gross, M. B. Personal Communication. Baltimore, Md. 9/2/2015. 3. Yang, X.-H., Huang, S. PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor locus on human chromosome 12q23-q24.1. Genomics 61: 319-325, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Eva-1 homolog A, regulator of programmed cell death

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.