Anti-PREX2 Antibody Picoband® fluoro488 Vervoeging

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene. The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3) -dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.

Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3, NEUR

PREX2

80243

Q70Z35

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human PREX2 recombinant protein (Position: D582-Q1094) .

Brain.

Flow Cytometry

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Immunogen affinity purified.

Liquid

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM) . Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

1. Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., Zhang, H., Zeid, R., and 36 others. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485: 502-506, 2012. 2. Donald, S., Hill, K., Lecureuil, C., Barnouin, R., Krugmann, S., Coadwell, W. J., Andrews, S. R., Walker, S. A., Hawkins, P. T., Stephens, L. R., Welch, H. C. E. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 572: 172-176, 2004. 3. Donald, S., Humby, T., Fyfe, I., Segonds-Pichon, A., Walker, S. A., Andrews, S. R., Coadwell, W. J., Emson, P., Wilkinson, L. S., Welch, H. C. E. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc. Nat. Acad. Sci. 105: 4483-4488, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

104553 MW

6

Neurocan

Secreted .

AP-2 complex subunit beta

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.