Anti-PRKRA Konijn Monoklonale Antilichaam

Boster Bio Anti-PRKRA Rabbit Monoclonal Antibody catalog # M02744. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; HNRNPC; HNRPC

PRKRA

8575

O75569

Human, Mouse, Rat

A synthesized peptide derived from human PRKRA

Clone: 23P32

Widely expressed.

WB, IHC

Chromosome Structure, Epigenetics and Nuclear Signaling

Affinity-chromatography

0.5mg/ml

Liquid

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621) . Specifically recognizes and binds N6- methyladenosine (m6A) -containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non- coding RNAs (lncRNAs) via a mechanism named 'm (6) A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671) . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre- mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'- UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M02744

33670 MW

32 kDa

Heterogeneous nuclear ribonucleoproteins C1/C2

Nucleus. Component of ribonucleosomes.

T-cell surface glycoprotein CD3 zeta chain

IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.