Anti-PRODH Antibody Picoband®

Proline dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the PRODH gene. This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4) . This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Boster Bio Anti-PRODH Antibody Picoband® catalog # A03231-3. Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Peptidyl-prolyl cis-trans isomerase B; PPIase B; 5.2.1.8; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP; PPIB; CYPB

PRODH

5625

O43272

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PRODH recombinant protein (Position: H116-E433) .

Found mainly in the liver, kidney and skeletal muscle.

WB, IHC, Flow Cytometry, ELISA

ER Proteins, Immunology, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1. Afenjar, A., Moutard, M.-L., Doummar, D., Guet, A., Rabier, D., Vermersch, A.-I., Mignot, C., Burglen, L., Heron, D., Thioulouse, E., de Villemeur, T. B., Campion, D., Rodriguez, D. Early neurological phenotype in 4 children with biallelic PRODH mutations. Brain Dev. 29: 547-552, 2007. 2. Baron, M. Genetics of schizophrenia and the new millennium: progress and pitfalls. Am. J. Hum. Genet. 68: 299-312, 2001. 3. Bender, H.-U., Almashanu, S., Steel, G., Hu, C.-A., Lin, W.-W., Willis, A., Pulver, A., Valle, D. Functional consequences of PRODH missense mutations. Am. J. Hum. Genet. 76: 409-420, 2005.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A03231-3

37836 MW

69 kDa

6

Peptidylprolyl isomerase B

Endoplasmic reticulum lumen

Thrombopoietin

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.