Anti-profiline 2/PFN2 Antibody Picoband® fluoro594 Vervoeging

Profilin-2, also called PFN2, is a protein that in humans is encoded by the PFN2 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. This gene is mapped to 3q25.1. It is though to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. It binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Profilin-2; Profilin II; PFN2

PFN2

5217

P35080

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Profilin 2, identical to the related mouse and rat sequences.

Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.

Flow Cytometry

Actin, Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

1. Gieselmann, R., Kwiatkowski, D. J., Janmey, P. A., Witke, W. Distinct biochemical characteristics of the two human profilin isoforms. Europ. J. Biochem. 229: 621-628, 1995. 2. Joensuu, T., Blanco, G., Pakarinen, L., Sistonen, P., Kaariainen, H., Brown, S., de la Chapelle, A., Sankila, E.-M. Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region. Genomics 38: 255-263, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

15 kDa

No cross reactivity with other proteins.

6

Profilin-2

Cytoplasm, cytoskeleton.

Contains 17 laminin EGF-like domains.

Profilin-2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.