Anti-Progesteron Receptor/PGR Antibody Picoband® 31.0550 Vervoeging

The progesterone receptor (PR) is an intracellular steroid receptor that specially binds progesterone in humans. PR has been a member of the steroid receptor superfamily. It is encoded by a single PGR gene residing on chromosome 11q22. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. It can be observed in human breast tissues. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner.

Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3

PGR

5241

P06401

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human Progesterone Receptor, identical to the related rat and mouse sesquences.

Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. .

Flow Cytometry

Cancer, Domain Families, Endocrine System, Epigenetics and Nuclear Signaling, Neuroscience, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription, Tumor Biomarkers, Zinc Finger

Immunogen affinity purified.

Liquid

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.

1. Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (March 1987) . Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem. Biophys. Res. Commun. 143 (2) : 740–8. 2. Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (May 1987) . The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2. Proc. Natl. Acad. Sci. U.S.A. 84 (9) : 2877–81. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240. 3. Nishihara T, Kitaura M, Imagawa M, Nishikawa J (1995) . Vitamin D receptor contains multiple dimerization interfaces that are functionally different. Nucleic Acids Res. 23 (4) : 606–611. 4. Schmitt J, De Vos P, Verhoeven G, Stunnenberg HG (1994) . Human androgen receptor expressed in HeLa cells activates transcription in vitro. Nucleic Acids Res. 22 (7) : 1161–1166.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

98981 MW

No cross reactivity with other proteins.

6

Progesterone receptor

Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2) /M phases.

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Progesterone receptor (PR)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.