Anti-proproteïne convertase PC4/PCSK4 Antibody Picoband® fluoro488 Vervoeging

PCSK4 (Proprotein Convertase, Subtilisin/Kexin-Type, 4), is an enzyme that in humans is encoded by the PCSK4 gene. The gene for PC4 (Pcsk4 locus) was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al. (2005) found that aberrant processing of pro-IGF2 by PC4 may be a cause of IUGR. PC4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2 (1-102) . Mature IGF2 (1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of PC4 by a PC4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.

Proprotein convertase subtilisin/kexin type 4;3.4.21.-; KEX2-like endoprotease 3; Neuroendocrine convertase 3; NEC 3; Prohormone convertase 3; Pcsk4; Nec-3, Nec3

PCSK4

18551

P29121

Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of mouse Proprotein convertase PC4, different from the related rat sequence by one amino acid.

Expressed abundantly in the testis. .

Flow Cytometry

Cell Biology, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Liquid

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.

1. Cao, H., Mok, A., Miskie, B., Hegele, R. A. Single-nucleotide polymorphisms of the proprotein convertase subtilisin/kexin type 5 (PCSK5) gene. J. Hum. Genet. 46: 730-732, 2001. 2. Mbikay, M., Seidah, N. G., Chretien, M., Simpson, E. M. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. Genomics 26: 123-129, 1995. 3. Qiu, Q., Basak, A., Mbikay, M., Tsang, B. K., Gruslin, A. Role of pro-IGF-II processing by proprotein convertase 4 in human placental development. Proc. Nat. Acad. Sci. 102: 11047-11052, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

73214 MW

No cross reactivity with other proteins.

6

Proprotein convertase subtilisin/kexin type 4

Cytoplasmic vesicle, secretory vesicle. Localized in the secretion granules.

Belongs to the peptidase S8 family. Furin subfamily.

Proprotein convertase subtilisin/kexin type 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.