Anti-PROSER3 Antibody Picoband® fluoro594 Vervoeging

The function of this protein remains unknown.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

PROSER3

148137

Q2NL68

Human

No cross-reactivity with other proteins.

E.coli-derived human PROSER3 recombinant protein (Position: D2-R426) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Zhang, Y. , Shang, L. , Zhang, J. , Liu, Y. , Jin, C. , & Zhao, Y. , et al. (2022) . An antibody-based proximity labeling map reveals mechanisms of sars-cov-2 inhibition of antiviral immunity. 2. Gordon, D. E. , Hiatt, J. , Bouhaddou, M. , Rezelj, V. V. , & Shun-Shion, A. S. . (2020) . Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370 (6521) . 3. William, B, Redwin, Morgan, E, & DeSanti, et al. (2017) . The human cytoplasmic dynein interactome reveals novel activators of motility. Elife.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.