Anti-Prostaglandin E Receptor EP1/PTGER1 Antibody Picoband® fluoroc647 Vervoeging

PTGER1, Prostaglandin E Receptor 1, comprises 402 amino acids with a predicted molecular mass of 41, 858 and has the 7 predicted transmembrane-spanning domains common to all G protein-coupled receptors. The PTGER1 gene is mapped to chromosome 19p13.1. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2) . Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.

Prostaglandin E2 receptor EP1 subtype; PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor; PTGER1

PTGER1

5731

P34995

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Prostaglandin E Receptor EP1.

Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Flow Cytometry

G Protein Signaling, Lipid Signaling, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Receptor for prostaglandin E2 (PGE2) . The activity of this receptor is mediated by G (q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

1. Funk, C. D., Furci, L., FitzGerald, G. A., Grygorczyk, R., Rochette, C., Bayne, M. A., Abramovitz, M., Adam, M., Metters, K. M.Cloning and expression of a cDNA for the human prostaglandin E receptor EP-1 subtype.J. Biol. Chem. 268: 26767-26772, 1993. 2. Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., Kitaoka, S., Ushikubi, F., Nabeshima, T., Narumiya, S.Prostaglandin E receptor E1 controls impulsive behavior under stress.Proc. Nat. Acad. Sci. 102: 16066-16071, 2005 3. Stock, J. L., Shinjo, K., Burkhardt, J., Roach, M., Taniguchi, K., Ishikawa, T., Kim, H.-S., Flannery, P. J., Coffman, T. M., McNeish, J. D., Audoly, L. P.The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.J. Clin. Invest. 107: 325-331, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

41801 MW

No cross reactivity with other proteins.

6

Prostaglandin E2 receptor EP1 subtype

Cell membrane; Multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family.

Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype/PGE2 receptor EP1 subtype)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.