Anti-protein C/PROC Antibody Picoband® fluoro647 Vervoeging

Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated protein C concentrates had been described in case reports and in 1 uncontrolled series.

Vitamin K-dependent protein C;3.4.21.69; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; PROC

PROC

5624

P04070

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Protein C.

Plasma; synthesized in the liver.

Flow Cytometry

Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction

Immunogen affinity purified.

Liquid

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. .

1. Allaart, C. F., Poort, S. R., Rosendaal, F. R., Reitsma, P. H., Bertina, R. M., Briet, E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet 341: 134-138, 1993. 2. Beckmann, R. J., Schmidt, R. J., Santerre, R. F., Plutzky, J., Crabtree, G. R., Long, G. L. The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs. Nucleic Acids Res. 13: 5233-5247, 1985. 3. Berg, L.-P., Scopes, D. A., Alhaq, A., Kakkar, V. V., Cooper, D. N. Disruption of a binding site for hepatocyte nuclear factor 1 in the protein C gene promoter is associated with hereditary thrombophilia. Hum. Molec. Genet. 3: 2147-2152, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

52071 MW

No cross reactivity with other proteins.

6

Vitamin K-dependent protein C

Secreted .

Belongs to the peptidase S1 family.

Vitamin K-dependent protein C

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.