Anti-protein verzonden homolog 2 Disp2 Antilichaam

Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.

Boster Bio Anti-Protein dispatched homolog 2 Disp2 Antibody (Catalog # A14691) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

DISPB, HsT16908, DISPB, KIAA1742, Protein dispatched homolog 2

DISP2

A7MBM2

Human, Mouse, Rat

Disp2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Disp2. The immunogen is located within amino acids 1210 - 1260 of Disp2.

Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.

ELISA, WB

Signal Transduction

Disp2 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Probable methyltransferase. .

Disp2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A14691

152003 MW

Dispatched homolog 2 (Drosophila)

Membrane ; Multi-pass membrane protein .

Dispatched homolog 2 (Drosophila)

IgG

Disp2 Antibody is supplied in PBS containing 0.02% sodium azide.