Anti-protein Wnt-2b Wnt2b Antibody Picoband® 31.0647 Vervoeging

WNT2B (Wingless-Type MMTV Integration Site Family Member 2B), is a protein that in humans is encoded by the WNT2B gene. This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. Katoh et al. (1996) used fluorescence in situ hybridization to map the WNT13 gene to chromosome 1p13. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis.

Protein Wnt-2b; Protein Wnt-13; WNT2B; WNT13

WNT2B

7482

Q93097

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human Wnt2b, identical to the related rat and mouse sequences.

Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.

Flow Cytometry

Cancer, Oncoproteins/Suppressors, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Tumor Suppressors

Immunogen affinity purified.

Liquid

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.

1. Katoh, M., Hirai, M., Sugimura, T., Terada, M. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. Oncogene 13: 873-876, 1996. 2. Ober, E. A., Verkade, H., Field, H. A., Stainier, D. Y. R. Mesodermal Wnt2b signalling positively regulates liver specification. Nature 442: 688-691, 2006. 3. Wolda, S. L., Moon, R. T. Cloning and developmental expression in Xenopus laevis of seven additional members of the Wnt family. Oncogene 7: 1941-1947, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

43770 MW

No cross reactivity with other proteins.

6

Protein Wnt-2b

Secreted, extracellular space, extracellular matrix.

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein Wnt-2b

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.