Anti-protein Wnt-3a Wnt3a Antibody Picoband® 0,00647 Vervoeging

Wingless-type MMIV integration site family, member 3A is a protein that in humans is encoded by the WNT3A gene. This gene is a member of the WNT gene family. The gene was assigned to human chromosome 1q42.13. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product.

Protein Wnt-3a; WNT3A

WNT3A

89780

P56704

Human, Mouse

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Wnt3a, identical to the related mouse sequence.

Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.

Flow Cytometry

Developmental Biology, Embryogenesis, Neurogenesis, Neurology Process, Neuroscience, Secreted, Signaling Pathways, Stem Cells

Immunogen affinity purified.

Liquid

Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.

1. Aulehla, A., Herrmann, B. G. Segmentation in vertebrates: clock and gradient finally joined. Genes Dev. 18: 2060-2067, 2004. 2. Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., Rando, T. A. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317: 807-810, 2007. 3. Saitoh T, Hirai M, Katoh M (Jun 2001) . Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region. Biochem Biophys Res Commun 284 (5) : 1168–75.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39365 MW

No cross reactivity with other proteins.

6

Protein Wnt-3a

Secreted, extracellular space, extracellular matrix.

Belongs to the Wnt family.

Protein Wnt-3a

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.