Anti-protein Wnt-4 Wnt4 Antibody Picoband® fluoroc647 Vervoeging

Wingless-type MMIV integration site family, member4, is a secreted protein that in humans is encoded by the Wnt4 gene. By fluorescence in situ hybridization, WNT4 gene was mapped to chromosome 1p35, a location consistent with the results of radiation hybrid mapping. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryogenesis.

Protein Wnt-4; WNT4; UNQ426/PRO864

WNT4

54361

P56705

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Wnt4, identical to the related mouse and rat sequences.

Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.

Flow Cytometry

Adapters, Cancer, Developmental Biology, Oncoproteins/Suppressors, Organogenesis, Reproduction, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Transmembrane, Tumor Suppressors

Immunogen affinity purified.

Liquid

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity) . Overexpression may be associated with abnormal proliferation in human breast tissue. .

1. Biason-Lauber, A., De Filippo, G., Konrad, D., Scarano, G., Nazzaro, A., Schoenle, E. J. WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum. Reprod. 22: 224-229, 2007. 2. Biason-Lauber, A., Konrad, D., Navratil, F., Schoenle, E. J. A WNT4 mutation associated with mullerian-duct regression and virilization in a 46, XX woman. New Eng. J. Med. 351: 792-798, 2004. 3. Garnis, C., Campbell, J., Davies, J. J., MacAulay, C., Lam, S., Lam, W. L. Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis. Hum. Molec. Genet. 14: 475-482, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39052 MW

No cross reactivity with other proteins.

6

Protein Wnt-4

Secreted, extracellular space, extracellular matrix.

Belongs to the Wnt family.

Protein Wnt-4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.