Anti-PRPF31 Antibody Picoband® fluoro488 Vervoeging

PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae), also known as PRPF31, is a protein which in humans is encoded by the PRPF31 gene. This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.

Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; CD357; Tnfrsf18; Gitr

PRPF31

26121

Q8WWY3

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PRPF31 recombinant protein (Position: K73-K488) .

Detected in thymus and in activated splenocytes.

Flow Cytometry

Adaptive Immunity, Cancer, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction

Immunogen affinity purified.

Liquid

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

1. Al-Maghtheh, M., Vithana, E., Tarttelin, E., Jay, M., Evans, K., Moore, T., Bhattacharya, S., Inglehearn, C. F. Evidence for a major retinitis pigmentosa locus on 19q13.4 (RP11), and association with a unique bimodal expressivity phenotype. Am. J. Hum. Genet. 59: 864-871, 1996. 2. Berson, E. L., Gouras, P., Gunkel, R. D., Myrianthopoulos, N. C. Dominant retinitis pigmentosa with reduced penetrance. Arch. Ophthal. 81: 226-234, 1969. 3. Deery, E. C., Vithana, E. N., Newbold, R. J., Gallon, V. A., Bhattacharya, S. S., Warren, M. J., Hunt, D. M., Wilkie, S. E. Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31. Hum. Molec. Genet. 11: 3209-3219, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26000 MW

6

Tumor necrosis factor receptor superfamily, member 18

Cell membrane. Single-pass type I membrane protein. Secreted.

Transcription factor E2F3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.