Anti-PRPF39 Antibody Picoband® fluoro488 Vervoeging

Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP; U2-type prespliceosome; and commitment complex.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

PRPF39

55015

Q86UA1

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PRPF39 recombinant protein (Position: D149-Y664) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 11/2/2012. 2. Stark, A. L., Delaney, S. M., Wheeler, H. E., Im, H. K., Dolan, M. E. Functional consequences of PRPF39 on distant genes and cisplatin sensitivity. Hum. Molec. Genet. 21: 4348-4355, 2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.