Anti-PRR9 Antibody Picoband® 31.0550 Vervoeging

Proline rich 9 is a protein that in humans is encoded by the PRR9 gene. PRR9 is pseudo-response regulator. It involved in clock function. PRR7 and PRR9 are partially redundant essential components of a temperature-sensitive circadian system.

Interactor of HORMAD1 protein 1; Cancer/testis antigen 74; CT74; Coiled-coil domain-containing protein 36; CCDC36; IHO1

PRR9

574414

Q5T870

Human, Mouse

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence in the middle region of human PRR9, which shares 82.6% amino acid (aa) sequence identity with mouse PRR9.

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Gaudet P, Livstone MS, Lewis SE, Thomas PD. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12 (5) :449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. PMID: 21873635; PMCID: PMC3178059. 2. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A. A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 15;474 (7351) :337-42. doi: 10.1038/nature10163. PMID: 21677750; PMCID: PMC3572410.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

Coiled-coil domain containing 36

Chromosome.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.