Anti-PRRG1 Antibody Picoband® 0,00647 Vervoeging

This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla) -containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

PRRG1

5638

O14668

Human

No cross-reactivity with other proteins

E.coli-derived human PRRG1 recombinant protein (Position: R3-N201) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Gross, M. B. Personal Communication. Baltimore, Md. 11/12/2014. 2. Kulman, J. D., Harris, J. E., Haldeman, B. A., Davie, E. W. Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins. Proc. Nat. Acad. Sci. 94: 9058-9062, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.