Anti-PSMC4 Antibody Picoband® fluoro488 Vervoeging

26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit Rpt3, is an enzyme that in humans is encoded by the PSMC4 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Rhombotin-1; Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1; LMO1; RBTN1, RHOM1, TTG1

PSMC4

5704

P43686

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PSMC4 recombinant protein (Position: M1-Q412) .

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus. .

Flow Cytometry

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription

Immunogen affinity purified.

Liquid

May be involved in gene regulation within neural lineage cells potentially by DNA binding or by binding to other transcription factors. .

1. Dubiel, W., Ferrell, K., Rechsteiner, M. Tat-binding protein 7 is a subunit of the 26S protease. Biol. Chem. Hoppe Seyler 375: 237-240, 1994. 2. Ohana, B., Moore, P. A., Ruben, S. M., Southgate, C. D., Green, M. R., Rosen, C. A. The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. Proc. Nat. Acad. Sci. 90: 138-142, 1993. 3. Sakao, Y., Kawai, T., Takeuchi, O., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Takeda, K., Akira, S. Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. Genomics 67: 1-7, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

47 kDa

6

Rhombotin-1

Nucleus .

Rhombotin-1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.