Anti-PSMD4 Antibody Picoband® 31.0550 Vervoeging

26S proteasome non-ATPase regulatory subunit 4, also as known as 26S Proteasome Regulatory Subunit Rpn10 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD4 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

Zona pellucida sperm-binding protein 3; Sperm receptor; ZP3A/ZP3B; Zona pellucida glycoprotein 3; Zp-3; Zona pellucida protein C; ZP3; ZP3A; ZP3B; ZPC

PSMD4

5710

P55036

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PSMD4 recombinant protein (Position: M1-E322) .

Oocytes.

Flow Cytometry

Cell Biology, Cell Type Markers, Developmental Biology, Reproduction, Tags & Cell Markers

Immunogen affinity purified.

Liquid

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

1. Deveraux, Q., Jensen, C., Rechsteiner, M. Molecular cloning and expression of a 26 S protease subunit enriched in dileucine repeats. J. Biol. Chem. 270: 23726-23729, 1995. 2. Deveraux, Q., Ustrell, V., Pickart, C., Rechsteiner, M. A 26 S protease subunit that binds ubiquitin conjugates. J. Biol. Chem. 269: 7059-7061, 1994. 3. Ferrell, K., Deveraux, Q., van Nocker, S., Rechsteiner, M. Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease. FEBS Lett. 381: 143-148, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

75187 MW

6

Zona pellucida glycoprotein 3

Extracellular matrix, Cell membrane, Single-pass type I membrane protein.

Segment polarity protein dishevelled homolog DVL-1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.