Anti-PSMD8 Antibody Picoband®

26S proteasome non-ATPase regulatory subunit 8 is an enzyme that in humans is encoded by the PSMD8 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.

Boster Bio Anti-PSMD8 Antibody Picoband® catalog # A12465-1. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

RNA-binding motif, single-stranded-interacting protein 3; RBMS3

PSMD8

5714

P48556

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PSMD8 recombinant protein (Position: A86-V350) .

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.

WB, IHC, ICC, IF, ELISA

DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, RNA Processing

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Binds poly (A) and poly (U) oligoribonucleotides.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/23/2018. 2. Kominami, K., DeMartino, G. N., Moomaw, C. R., Slaughter, C. A., Shimbara, N., Fujimoro, M., Yokosawa, H., Hisamatsu, H., Tanahashi, N., Shimizu, Y., Tanaka, K., Toh-e, A. Nin1p, a regulatory subunit of the 26S proteosome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. EMBO J. 14: 3105-3115, 1995.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A12465-1

47 kDa

RNA binding motif single stranded interacting protein 3

Cytoplasm.

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.