Anti-PTCH2 Antibody Picoband® 31.0550 Vervoeging

PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for  Ptch2  in adult epidermal homeostasis via Shh signaling.

Protein patched homolog 2; PTC2; PTCH2; UNQ560/PRO1121/PRO57079

PTCH2

8643

Q9Y6C5

Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human PTCH2, different from the related mouse sequence by one amino acid.

Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. .

Flow Cytometry

Signaling Pathways, Stem Cells, Surface Molecules

Immunogen affinity purified.

Liquid

May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) .

1. Nieuwenhuis, E., Motoyama, J., Barnfield, P. C., Yoshikawa, Y., Zhang, X., Mo, R., Crackower, M. A., Hui, C. Mice with a targeted mutation of Patched 2 are viable but develop alopecia and epidermal hyperplasia. Molec. Cell. Biol. 26: 6609-6622, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

130544 MW

No cross reactivity with other proteins.

6

Protein patched homolog 2

Membrane; Multi-pass membrane protein.

Belongs to the patched family.

Protein patched homolog 2 (PTC2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.