Anti-PTGES2/Gbf1 Antibody Picoband® fluoro488 Vervoeging

Microsomal prostaglandin E synthase-2 (mPGES-2) or Prostaglandin E synthase 2 is an enzyme that in humans encoded by the PTGES2 gene located on chromosome 9. The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE) . Multiple transcript variants have been found for this gene.

Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3, NEUR

PTGES2

80142

Q9H7Z7

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PTGES2/Gbf1 recombinant protein (Position: L100-I370) .

Brain.

Flow Cytometry

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Immunogen affinity purified.

Liquid

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM) . Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

1. Hu, J., Meng, Q., Roy, S. K., Raha, A., Hu, J., Zhang, J., Hashimoto, K., Kalvakolanu, D. V. A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J. Biol. Chem. 277: 30253-30263, 2002. 2. Nitz, I., Fisher, E., Grallert, H., Li, Y., Gieger, C., Rubin, D., Boeing, H., Spranger, J., Lindner, I., Schreiber, S., Rathmann, W., Gohlke, H., Doring, A., Wichmann, H.-E., Schrezenmeir, J., Doring, F., Illig, T. Association of prostaglandin E synthase 2 (PTGES2) arg298-to-his polymorphism with type 2 diabetes in two German study populations. J. Clin. Endocr. Metab. 92: 3183-3188, 2007. 3. Tanikawa, N., Ohmiya, Y., Ohkubo, H., Hashimoto, K., Kangawa, K., Kojima, M., Ito, S., Watanabe, K. Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem. Biophys. Res. Commun. 291: 884-889, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

104553 MW

6

Neurocan

Secreted .

AP-2 complex subunit beta

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.