Anti-PTGIS/BGAS Antibody Picoband®

Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Boster Bio Anti-PTGIS/PGIS Antibody Picoband® catalog # A05053-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

RNA-binding protein Musashi homolog 1; Musashi-1; MSI1

PTGIS

5740

Q16647

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PTGIS/PGIS recombinant protein (Position: D119-D470) .

Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.

WB, Flow Cytometry, ELISA

Cell Type Marker, Cytoplasmic, Intracellular, Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Nuclear, Signaling Pathways, Stem Cells

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U1-3AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.

1. Chevalier, D., Cauffiez, C., Bernard, C., Lo-Guidice, J.-M., Allorge, D., Fazio, F., Ferrari, N., Libersa, C., Lhermitte, M., D'Halluin, J.-C., Broly, F. Characterization of new mutations in the coding sequence and 5-prime-untranslated region of the human prostacyclin synthase gene (CYP8A1) . Hum. Genet. 108: 148-155, 2001. 2. Miyata, A., Hara, S., Yokoyama, C., Inoue, H., Ullrich, V., Tanabe, T. Molecular cloning and expression of human prostacyclin synthase. Biochem. Biophys. Res. Commun. 200: 1728-1734, 1994. 3. Nakayama, T., Soma, M., Watanabe, Y., Hasimu, B., Sato, M., Aoi, N., Kosuge, K., Kanmatsuse, K., Kokubun, S., Marrow, J. D., Oates, J. A. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Biochem. Biophys. Res. Commun. 297: 1135-1139, 2002.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A05053-2

39125 MW

57 kDa

6

Musashi RNA binding protein 1

Nucleus. Cytoplasm.

RNA-binding protein Musashi homolog 1

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.