Anti-PTP1B PTPN1 Konijn Monoklonale Antilichaam

Boster Bio Anti-PTP1B PTPN1 Rabbit Monoclonal Antibody catalog # M00613. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

Tyrosine-protein phosphatase non-receptor type 1;3.1.3.48; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1; PTP1B

PTPN1

5770

P18031

Human

A synthesized peptide derived from human PTP1B

Clone: IHG-16

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. .

WB, IHC, ICC, IF, Flow Cytometry

Protein Phosphorylation, Signal Transduction, Tyrosine Phosphatases

Affinity-chromatography

0.5mg/ml

Liquid

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00613

49967 MW

32-42 kDa, 65 kDa, 75 kDa

Tyrosine-protein phosphatase non-receptor type 1

Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Interacts with EPHA3 at the cell membrane.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.