Anti-PTPN2 Konijn Monoklonale Antilichaam

Boster Bio Anti-PTPN2 Rabbit Monoclonal Antibody catalog # M01597. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse.

E3 ubiquitin-protein ligase NEDD4-like;6.3.2.-; NEDD4.2; Nedd4-2; NEDD4L; KIAA0439, NEDL3

PTPN2

5770

P18031/P17706

Human, Mouse

A synthesized peptide derived from human PTPN2

Clone: 27P66

Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597) . Expressed in melanocytes (PubMed:23999003) . .

WB, IP, Flow Cytometry

Cell Biology, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Affinity-chromatography

0.5mg/ml

Liquid

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then ly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01597

111932 MW

40-48 kDa

E3 ubiquitin-protein ligase NEDD4-like

Cytoplasm . May be recruited to exosomes by NDFIP1.

Lysosome-associated membrane glycoprotein 2 (Lamp2)

IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.