Anti-PTPRE Antibody Picoband® 31.0550 Vervoeging

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.

PTPRE; Receptor-type tyrosine-protein phosphatase epsilon; Protein-tyrosine phosphatase epsilon; R-PTP-epsilon; EC 3.1.3.48

PTPRE

5791

P23469

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human PTPRE recombinant protein (Position: Q74-H591) . Human PTPRE shares 94.2% and 94.8% amino acid (aa) sequence identity with mouse and rat PTPRE, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Elson, A., Kozak, C. A., Morton, C. C., Weremowicz, S., Leder, P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics 31: 373-375, 1996. 2. Krueger, N. X., Streuli, M., Saito, H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9: 3241-3252, 1990. 3. Melhado, I. G., Anderson, L. L., Duncan, A. M. V., Jirik, F. R. The gene encoding protein-tyrosine phosphatase RPTP-epsilon (PTPRE) is assigned to human chromosome 10q26. Cytogenet. Cell Genet. 73: 168-170, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

81 kDa

6

Protein tyrosine phosphatase receptor type E

Receptor-type tyrosine-protein phosphatase epsilon

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.