Anti-PXK Antibody Picoband® 31.0550 Vervoeging

PX domain containing serine/threonine kinase also known as PXK is a protein which in humans is encoded by the PXK gene. This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE) . Alternative splicing results in multiple transcript variants.

C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16; CCL16; ILINCK; NCC4; SCYA16

PXK

54899

Q7Z7A4

Human, Monkey

No cross-reactivity with other proteins.

E.coli-derived human PXK recombinant protein (Position: E5-K576) .

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Flow Cytometry

Angiogenesis, Cardiovascular, Chemokines, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation

Immunogen affinity purified.

Liquid

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

1. Mao, H., Ferguson, T. S., Cibulsky, S. M., Holmqvist, M., Ding, C., Fei, H., Levitan, I. B. MONaKA, a novel modulator of the plasma membrane Na, K-ATPase. J. Neurosci. 25: 7934-7943, 2005. 2. Zou, X., Qiu, G., Chen, C., Wu, M., Hu, Y., Zheng, H., Li, X., Gu, S., Ji, C., Mao, Y. Expression pattern and subcellular localization of five splice isoforms of human PXK. Int. J. Molec. Med. 16: 701-707, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

157578 MW

6

C-C motif chemokine ligand 16

Secreted.

BAG family molecular chaperone regulator 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.