Anti-PYHIN1 Antibody Picoband® fluoro488 Vervoeging

The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

PYHIN1

149628

Q6K0P9

Human, Mouse, Rat

E.coli-derived human PYHIN1 recombinant protein (Position: K86-H488) . Human PYHIN1 shares 45.6% amino acid (aa) sequence identity with mouse PYHIN1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Ding, Y., Lee, J.-F., Lu, H., Lee, M.-H., Yan, D.-H. Interferon-inducible protein IFIX-alpha-1 functions as a negative regulator of HDM2. Molec. Cell. Biol. 26: 1979-1996, 2006. 2. Ding, Y., Wang, L., Su, L.-K., Frey, J. A., Shao, R., Hunt, K. K., Yan, D.-H. Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Oncogene 23: 4556-4566, 2004. 3. Yamaguchi, H., Ding, Y., Lee, J.-F., Zhang, M., Pal, A., Bornmann, W., Yan, D.-H., Hung, M.-C. Interferon-inducible protein IFIX-alpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Molec. Carcinogen. 47: 739-743, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

55 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.