Anti-Quescin Q6/QSOX1 Antibody Picoband® fluoro647 Vervoeging

Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene. This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

QSOX1

5768

O00391

Human

No cross-reactivity with other proteins.

E.coli-derived human Quiescin Q6/QSOX1 recombinant protein (Position: R32-Q421) .

Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

1. Alon, A., Grossman, I., Gat, Y., Kodali, V. K., DiMaio, F., Mehlman, T., Haran, G., Baker, D., Thorpe, C., Fass, D. The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature 488: 414-418, 2012. 2. Coppock, D. L., Cina-Poppe, D., Gilleran, S. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. Genomics 54: 460-468, 1998. 3. Coppock, D. L., Kopman, C., Scandalis, S., Gilleran, S. Preferential gene expression in quiescent human lung fibroblasts. Cell Growth Differ. 4: 483-493, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Chemokine (C motif) ligand 1

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.