Anti-RAB36 Antibody Picoband® 31.0647 Vervoeging

Ras-related protein Rab-36 is a protein that in humans is encoded by the RAB36 gene. The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 36 is a ubiquitously expressed member of the Rab family of proteins and localizes to the Golgi membrane where it is believed to participate in protein transport. The gene encoding Rab 36 localizes to a critical region of chromosome 22 that is often deleted or involved in translocations in malignant rhabdoid tumors (MRTs) . This suggests that Rab 36 may play a role in the development of MRTs.

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

RAB36

9609

O95755

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human RAB36 recombinant protein (Position: Q56-E323) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

1. Mori, T., Fukuda, Y., Kuroda, H., Matsumura, T., Ota, S., Sugimoto, T., Nakamura, Y., Inazawa, J. Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. Biochem. Biophys. Res. Commun. 254: 594-600, 1999. 2. Zhou, J.-Y., Fogelgren, B., Wang, Z., Roe, B. A., Biegel, J. A. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. Gene 241: 133-141, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

DAP3 binding cell death enhancer 1

Mitochondrion.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.