Anti-RAB39A/B Antibody Picoband® fluoro488 Vervoeging

This gene encodes a protein which is a member of the Rab family.The Rab family of proteins is a member of the Ras superfamily of monomeric G proteins. Approximately 70 types of Rabs have now been identified in humans. Rab GTPases regulate many steps of membrane traffic, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. These processes make up the route through which cell surface proteins are trafficked from the Golgi to the plasma membrane and are recycled. Surface protein recycling returns proteins to the surface whose function involves carrying another protein or substance inside the cell, such as the transferrin receptor, or serves as a means of regulating the number of a certain type of protein molecules on the surface.

Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7

RAB39A/B

54734/116442

Q14964/Q96DA2

Human

No cross-reactivity with other proteins.

E.coli-derived human RAB39A/B recombinant protein (Position: M1-C217) .

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins

Immunogen affinity purified.

Liquid

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .

1. Becker, C. E., Creagh, E. M., O'Neill, L. A. J. Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1-beta secretion. J. Biol. Chem. 284: 34531-34537, 2009. Note: Erratum: J. Biol. Chem. 291: 24800 only, 2016. 2. Cruz, F. M., Colbert, J. D., Rock, K. L. The GTPase Rab39a promotes phagosome maturation into MHC-I antigen-presenting compartments. EMBO J. 39: e102020, 2020. 3. Gross, M. B. Personal Communication. Baltimore, Md. 10/1/2021.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Interleukin 17B

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.