Anti-RAB7/RAB7A Antibody Picoband® fluoro488 Vervoeging

Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene. RAB7A functions as a key regulator in endo-lysosomal trafficking, governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end ed endosomal migration and positions, and endosome-lysosome transport through different protein-protein interaction cascades. Furthermore, RAB7A is involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes through modulation of SOX10 and the oncogene MYC. Mutations in the lysosomal pathway result in tumor progression in melanoma cells.

Nuclear pore complex protein Nup214; 214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN; NUP214; CAIN, CAN, KIAA0023

RAB7A

7879

P51149

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human RAB7/RAB7A recombinant protein (Position: K21-E177) .

Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.

Flow Cytometry

Cytoplasmic, Signaling Pathways, Stem Cells

Immunogen affinity purified.

Liquid

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.

1. Entrez Gene: RAB7A RAB7A, member RAS oncogene family. 2. Davies JP, Cotter PD, Ioannou YA (Apr 1997) . Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. Genomics 41 (1) : 131–4. 3. Kashuba VI, Gizatullin RZ, Protopopov AI, Allikmets R, Korolev S, Li J, Boldog F, Tory K, Zabarovska V, Marcsek Z, Sumegi J, Klein G, Zabarovsky ER, Kisselev L (Dec 1997) . NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors. FEBS Letters 419 (2-3) : 181–5.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

78948 MW

6

Nucleoporin 214

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity) . .

Segment polarity protein dishevelled homolog DVL-2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.