Anti-Rad18 Konijn Monoklonale Antilichaam

Boster Bio Anti-Rad18 Rabbit Monoclonal Antibody catalog # M01622. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

E3 ubiquitin-protein ligase RAD18;6.3.2.-; Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73; RAD18; RNF73

RAD18

56852

Q9NS91

Human, Mouse, Rat

A synthesized peptide derived from human Rad18

Clone: FFC-18

Expressed ubiquitously in normal tissues.

WB, Flow Cytometry

Cell Biology,2339, DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ring Finger E3 Ligase, Ubiquitin E3 Enzymes

Affinity-chromatography

0.5mg/ml

Liquid

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01622

56223 MW

28 kDa

E3 ubiquitin-protein ligase RAD18

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with chromatin (PubMed:25931565) . Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077) . Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607) . Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565) . .

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.