Anti-RAD21 Antibody Picoband® fluoro550 Vervoeging

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.

Tubulin beta chain; Tubulin beta-5 chain; TUBB; TUBB5; OK/SW-cl.56

RAD21

5885

O60216

Human, Mouse, Rat, Monkey

No cross-reactivity with other proteins

E.coli-derived human RAD21 recombinant protein (Position: D292-K529) .

Ubiquitously expressed with highest levels in spleen, thymus and immature brain.

Flow Cytometry

Cytoskeleton, Cytoskeleton/ECM, Microtubules, Signal Transduction, Subcellular Markers, Tags & Cell Markers, Tubulin

Immunogen affinity purified.

Liquid

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

1. Bonora, E., Bianco, F., Cordeddu, L., Bamshad, M., Francescatto, L., Dowless, D., Stanghellini, V. Cogliandro, R. F., Lindberg, G., Mungan, Z., Cefle, K., Ozcelik, T., and 14 others. Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction. Gastroenterology 148: 771-782, 2015. 2. Boyle, M. I., Jespersgaard, C., Nazaryan, L., Bisgaard, A.-M., Tumer, Z. A novel RAD21 variant associated with intrafamilial phenotypic variation in Cornelia de Lange syndrome--review of the literature. (Letter) Clin. Genet. 91: 647-649, 2017. 3. Deardorff, M. A., Wilde, J. J., Albrecht, M., Dickinson, E., Tennstedt, S., Braunholz, D., Monnich, M., Yan, Y., Xu, W., Gil-Rodriguez, M. C., Clark, D., Hakonarson, H., and 15 others. RAD21 mutations cause a human cohesinopathy. Am. J. Hum. Genet. 90: 1014-1027, 2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

50433 MW

6

Tubulin beta class I

Cytoskeleton

Tubulin beta chain

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.