Anti-RAGE Konijn Monoklonale Antilichaam

Boster Bio Anti-RAGE Rabbit Monoclonal Antibody catalog # M03438. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; AGER; RAGE

AGER

177

Q15109

Human, Mouse, Rat

A synthesized peptide derived from human RAGE

Clone: AOBF-1

Endothelial cells.

WB

Alzheimer's Disease, Atherosclerosis, Cardiovascular, Diabetes-associated, Neurodegenerative Disease, Neurology Process, Neuroscience, Sensory System, Vascular Inflammation, Visual System

Affinity-chromatography

0.5mg/ml

Liquid

Mediates interactions of advanced glycosylation end products (AGE) . These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity) . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M03438

42803 MW

150 kDa

Advanced glycosylation end product-specific receptor

Isoform 1: Cell membrane; Single-pass type I membrane protein.

T-cell surface glycoprotein CD3 zeta chain

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.