Anti-RANK/TNFRSF11A Antilichaam Picoband® 31.0550 Vervoeging

Receptor Activator of Nuclear Factor K B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL (Receptor Activator for Nuclear Factor K B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.

Tumor necrosis factor receptor superfamily member 11A; Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD265; TNFRSF11A; RANK

TNFRSF11A

8792

Q9Y6Q6

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human RANK.

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Flow Cytometry

Adapters, Atherosclerosis, Cardiovascular, Cytokines, Cytoskeleton/ECM, Extracellular Matrix, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Structures, TNF Superfamily, Transmembrane, Vascular Inflammation

Immunogen affinity purified.

Liquid

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. .

1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999) . Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20 (3) : 345–57. 2. Wong BR, Josien R, Choi Y (1999) . TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. J. Leukoc. Biol. 65 (6) : 715–24. 3. Theill LE, Boyle WJ, Penninger JM (2002) . RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20: 795–823.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

66034 MW

No cross reactivity with other proteins.

6

Tumor necrosis factor receptor superfamily member 11A

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Contains 4 TNFR-Cys repeats.

Tumor necrosis factor receptor superfamily member 11A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.