Anti-RASAL3 Antibody Picoband® PE Vervoeging

This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms.

RASAL3; RAS protein activator like-3

RASAL3

64926

Q86YV0

Human, Mouse

No cross-reactivity with other proteins

E.coli-derived human RASAL3 recombinant protein (Position: R48-Q925) . Human RASAL3 shares 82.4% amino acid (aa) sequence identity with mouse RASAL3.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Gross, M. B. Personal Communication. Baltimore, Md. 9/18/2015. 2. Saito, S., Kawamura, T., Higuchi, M., Kobayashi, T., Yoshita-Takahashi, M., Yamazaki, M., Abe, M., Sakimura, K., Kanda, Y., Kawamura, H., Jiang, S., Naito, M., Yoshizaki, T., Takahashi, M., Fujii, M. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. Europ. J. Immun. 45: 1512-1523, 2015.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

112 kDa

6

RAS protein activator like 3

RAS protein activator like-3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.