Anti-RASSF7 Antibody Picoband® fluoro550 Vervoeging

RASSF7 (Ras association domain-containing protein 7), also designated HRAS1-related cluster protein 1, is a 373 amino acid protein that localizes to the centrosome. RASSF7, RASSF8, RASSF9 and RASSF10 are four evolutionary conserved proteins that are collectively known as the N-terminal RASSF family. Expressed in skin, neural tube and eye, RASSF7 is believed to play an essential role in mitosis. Further supporting its mitotic role, knockdown of Xenopus RASSF7 has been shown to influence cell failure to form mitotic spindle and also cause nuclear breakdown and apoptosis.

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RASSF7

8045

Q02833

Human

No cross reactivity with other proteins.

E.coli-derived human RASSF7 recombinant protein (Position: R58-R342) . Human RASSF7 shares 77.5% amino acid (aa) sequence identity with mouse RASSF7.

Expressed in all tissues.

Flow Cytometry

Signal Transduction, Signaling Pathway, Small G Proteins

Immunogen affinity purified.

Liquid

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Sherwood, V., Manbodh, R., Sheppard, C., Chalmers, A. D. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Molec. Biol. Cell 19: 1772-1782, 2008. 2. Weitzel, J. N., Kasperczyk, A., Mohan, C., Krontiris, T. G. The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain. Genomics 14: 309-319, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

52588 MW

6

Serine/threonine-protein kinase AtPK1/AtPK6

Cytoplasm. Nucleus.

Serine/threonine-protein kinase AtPK1/AtPK6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.