Anti-RAX2 Antibody Picoband® 0,00647 Vervoeging

This gene encodes a homeodomain-containing protein that plays a role in eye development. Mutation of this gene causes age-related macular degeneration type 6, an eye disorder resulting in accumulations of protein and lipid beneath the retinal pigment epithelium and within the Bruch's membrane. Defects in this gene can also cause cone-rod dystrophy type 11, a disease characterized by the initial degeneration of cone photoreceptor cells and resulting in loss of color vision and visual acuity, followed by the degeneration of rod photoreceptor cells, which progresses to night blindness and the loss of peripheral vision. Alternative splicing results in multiple transcript variants.

RNA-binding protein Nova-2; Astrocytic NOVA1-like RNA-binding protein; Neuro-oncological ventral antigen 2; NOVA2; ANOVA; NOVA3

RAX2

84839

Q96IS3

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human RAX2.

Brain. Expression restricted to astrocytes.

Flow Cytometry

Channels, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

May regulate RNA splicing or metabolism in a specific subset of developing neurons. Binds single strand RNA.

1. Wang, Q., Chen, S., Esumi, N., Swain, P. K., Haines, H. S., Peng, G., Melia, M., McIntosh, I., Heckenlively, J. R., Jacobson, S. G., Stone, E. M., Swaroop, A., Zack, D. J. QRX, a novel homeobox gene, modulates photoreceptor gene expression. Hum. Molec. Genet. 13: 1025-1040, 2004. 2. Yang, P., Chiang, P.-W., Weleber, R. G., Pennesi, M. E. Autosomal dominant retinal dystrophy with electronegative waveform associated with a novel RAX2 mutation. JAMA Ophthal. 133: 653-661, 2015.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

29370 MW

6

NOVA alternative splicing regulator 2

Nucleus.

Aquaporin-6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.