Anti-RBM14 Antibody Picoband® fluoro488 Vervoeging

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene. This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene.

Meiotic recombination protein REC8 homolog; Cohesin Rec8p; REC8; REC8L1

RBM14

10432

Q96PK6

Human

No cross-reactivity with other proteins.

E.coli-derived human RBM14 recombinant protein (Position: M1-M669) .

Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa.

Flow Cytometry

Vasculature

Immunogen affinity purified.

Liquid

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.

1. Fox, A. H., Lam, Y. W., Leung, A. K. L., Lyon, C. E., Andersen, J., Mann, M., Lamond, A. I. Paraspeckles: a novel nuclear domain. Curr. Biol. 12: 13-25, 2002. 2. Iwasaki, T., Chin, W. W., Ko, L. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM) . J. Biol. Chem. 276: 33375-33383, 2001. 3. Perani, M., Antonson, P., Hamoudi, R., Ingram, C. J. E., Cooper, C. S., Garrett, M. D., Goodwin, G. H. The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. J. Biol. Chem. 280: 42863-42876, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

56903 MW

6

REC8 meiotic recombination protein

Nucleus. Chromosome. Centromere.

Vesicular acetylcholine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.