Anti-RBP1 Antibody Picoband® 31.0550 Vervoeging

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene. This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene.

SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; UBA2; SAE2; UBLE1B; HRIHFB2115

RBP1

5947

P09455

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human RBP1 recombinant protein (Position: K10-Q135) .

Duodenum, heart, lung and liver, but not thymus.

Flow Cytometry

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

Immunogen affinity purified.

Liquid

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

1. Colantuoni, V., Cortese, R., Nilsson, M., Lundvall, J., Bavik, C. O., Eriksson, U., Peterson, P. A., Sundelin, J. Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. Biochem. Biophys. Res. Commun. 130: 431-439, 1985. 2. Colantuoni, V., Rocchi, M., Roncuzzi, L., Romeo, G. Mapping of human cellular retinol-binding protein to chromosome 3. Cytogenet. Cell Genet. 43: 221-222, 1986. 3. De Baere, E., Speleman, F., Van Roy, N., De Paepe, A., Messiaen, L. Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta-prime subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. Cytogenet. Cell Genet. 82: 226-227, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64133 MW

6

Ubiquitin like modifier activating enzyme 2

Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

Heterogeneous nuclear ribonucleoprotein L

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.