Anti-REG1A/1B Antibody Picoband® 31.0647 Vervoeging

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.

Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex; MTA2; MTA1L1; PID

REG1A/1B

5967/5968

P05451/P48304

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human REG1A/1B recombinant protein (Position: N51-E90) .

Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Flow Cytometry

Domain Families, Epigenetics and Nuclear Signaling, Forkhead Box, Transcription

Immunogen affinity purified.

Liquid

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

1. Acquatella-Tran Van Ba, I., Marchal, S., Francois, F., Silhol, M., Lleres, C., Michel, B., Benyamin, Y., Verdier, J.-M., Trousse, F., Marcilhac, A. Regenerating islet-derived 1-alpha (Reg-1-alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin tumor-like 3 (EXTL3) receptor. J. Biol. Chem. 287: 4726-4739, 2012. 2. Akiyama, T., Takasawa, S., Nata, K., Kobayashi, S., Abe, M., Shervani, N. J., Ikeda, T., Nakagawa, K., Unno, M., Matsuno, S., Okamoto, H. Activation of Reg gene, a gene for insulin-producing beta-cell regeneration: poly (ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly (ADP-ribosyl) ation. Proc. Nat. Acad. Sci. 98: 48-53, 2001. 3. Bartoli, C., Gharib, B., Giorgi, D., Sansonetti, A., Dagorn, J.-C., Berge-Lefranc, J.-L. A gene homologous to the reg gene is expressed in human pancreas. FEBS Lett. 327: 289-293, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49162 MW

6

Metastasis associated 1 family member 2

Nucleus.

Transcription factor E2F3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.