Anti-resistine/RETN Antibody Picoband® fluoro550 Vervoeging

Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich protein that in humans is encoded by the RETN gene. The resistin gene comprises 4 exons, the first of which is untranslated, and spans approximately 1,750 bp. The human resistin gene is localized to a cloned fragment of human chromosome 19. In primates, pigs and dogs, resistin is secreted by immune and epithelial cells while in rodents, it is secreted by adipose tissue. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus.

Resistin; Adipose tissue-specific secretory factor; ADSF; Adipose-specific cysteine-rich secreted protein A12-alpha; Cysteine-rich secreted protein FIZZ3; Retn; Fizz3

RETN

57264

Q99P87

Mouse

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Resistin.

Expressed in white but not brown adipose tissue in a variety of organs.

Flow Cytometry

Atherosclerosis, Cardiovascular, Diabetes-associated, Energy Metabolism, Energy Transfer Pathways, Growth Factors/Hormones, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

1. Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A., Henzel, W., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., Frantz, G. D., Tumas, D. B., Peale, F. V., Jr., Shelton, D. L., Hebert, C. C.FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family.EMBO J. 19: 4046-4055, 2000. 2. Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., Lazar, M. A.The hormone resistin links obesity to diabetes.Nature 409: 307-312, 2001. 3. Wang, H., Chu, W. S., Hemphill, C., Elbein, S. C.Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians.J. Clin. Endocr. Metab. 87: 2520-2524, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

12492 MW

No cross reactivity with other proteins.

6

Resistin

Secreted.

Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.

Resistin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.