Anti-Reticulon-4-receptor-achtige 2 RTN4RL2 Antilichaam

Reticulon 4 receptor-like 2 (RTN4RL2), also known as NgR2and NgRH1, is a 60 kDa glycosylphosphatidylinositol-anchored protein that is expressed primarily in the brain. It contains eight leucine-rich repeats that are flanked by cysteine-rich sequences at both the N- and C-termini. The membrane anchored RTN4RL2 can be solubilized through the action of phospholipase or an unidentified MTMMP to generate a 46 kDa soluble receptor. It has been suggested that RTN4RL2 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

Boster Bio Anti-Reticulon-4 receptor-like 2 RTN4RL2 Antibody (Catalog # A10682) . Tested in ELISA, WB applications. This antibody reacts with Human.

NgR2, NGRH1, NGRL3, Reticulon-4 receptor-like 2, Nogo receptor-like 3, NgR2

RTN4RL2

Q86UN3

Human

Three alternatively spliced transcript variants have been observed. RTN4RL2 antibody is predicted to not cross-react with other Nogo receptor-like proteins.

Rabbit polyclonal RTN4RL2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RTN4RL2. The immunogen is located within amino acids 330 - 380 of RTN4RL2.

Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.

ELISA, WB

Neuroscience

RTN4RL2 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity) . Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity) . Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200) . Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200) .

RTN4RL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

https://www.bosterbio.com/msds?sku=A10682

46106 MW

Reticulon 4 receptor-like 2

Cell membrane

Rat, Mouse

Reticulon 4 receptor-like 2

IgG

RTN4RL2 Antibody is supplied in PBS containing 0.02% sodium azide.