Anti-RGL4 Antibody Picoband® 31.0550 Vervoeging

This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

RGL4

266747

Q8IZJ4

Human

No cross-reactivity with other proteins.

E.coli-derived human RGL4 recombinant protein (Position: R37-R381) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Hernandez-Munoz, I., Benet, M., Calero, M., Jimenez, M., Diaz, R., Pellicer, A. rgr oncogene: activation by elimination of translational controls and mislocalization. Cancer Res. 63: 4188-4195, 2003. 2. Leonardi, P., Kassin, E., Hernandez-Munoz, I., Diaz, R., Inghirami, G., Pellicer, A. Human rgr: transforming activity and alteration in T-cell malignancies. Oncogene 21: 5108-5116, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.