Anti-RHBDF2 Antibody Picoband® 0,00647 Vervoeging

Rhomboid family member 2 is a protein that in humans is encoded by the RHBDF2 gene. Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome.

Chromaffin granule amine transporter; Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1; SLC18A1; VAT1; VMAT1

RHBDF2

79651

Q6PJF5

Human

No cross-reactivity with other proteins.

E.coli-derived human RHBDF2 recombinant protein (Position: H145-D529) .

Highly expressed in chromaffin cells of the adrenal medulla (at protein level) . Detected in peripheral sympathetic ganglia (at protein level) . Found in some paracrine cells in stomach and duodenum (at protein level) .

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.

1. Adrain, C., Zettl, M., Cristova, Y., Taylor, N., Freeman, M. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science 335: 225-228, 2012. 2. Blaydon, D. C., Etheridge, S. L., Risk, J. M., Hennies, H.-C., Gay, L. J., Carroll, R., Plagnol, V., McRonald, F. E., Stevens, H. P., Spurr, N. K., Bishop, D. T., Ellis, A., Jankowski, J., Field, J. K., Leigh, I. M., South, A. P., Kelsell, D. P. RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. Am. J. Hum. Genet. 90: 340-346, 2012. 3. Brooke, M. A., Etheridge, S. L., Kaplan, N., Simpson, C., O'Toole, E. A., Ishida-Yamamoto, A., Marches, O., Getsios, S., Kelsell, D. P. iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. Hum. Molec. Genet. 23: 4064-4076, 2014.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

Solute carrier family 18 member A1

Cytoplasmic vesicle membrane. Multi-pass membrane protein. Synaptic vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.