Anti-RIMBP2 Antibody Picoband® 0,00647 Vervoeging

RIMS binding protein 2 is a protein that in humans is encoded by the RIMBP2 gene. Predicted to be involved in neuromuscular synaptic transmission. Predicted to be located in plasma membrane and synapse. Predicted to be active in presynaptic active zone cytoplasmic component.

Transmembrane protein 240; TMEM240; C1orf70

RIMBP2

23504

O15034

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human RIMBP2 recombinant protein (Position: K351-H1049) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Mittelstaedt, T., Schoch, S. Structure and evolution of RIM-BP genes: identification of a novel family member. Gene 403: 70-79, 2007. 2. Nagase, T., Ishikawa, K., Nakajima, D., Ohira, M., Seki, N., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4: 141-150, 1997. 3. Wang, Y., Sugita, S., Sudhof, T. C. The RIM/NIM family of neuronal C2 domain proteins: interactions with Rab3 and a new class of Src homology 3 domain proteins. J. Biol. Chem. 275: 20033-20044, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

19908 MW

6

Transmembrane protein 240

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.