Anti-RNF111 Antibody Picoband® 31.0550 Vervoeging

E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene. The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

RNF111

54778

Q6ZNA4

Human, Mouse, Rat

E.coli-derived human RNF111 recombinant protein (Position: F134-S994) .

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Episkopou, V., Arkell, R., Timmons, P. M., Walsh, J. J., Andrew, R. L., Swan, D. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature 410: 825-830, 2001. 2. Niederlander, C., Walsh, J. J., Episkopou, V., Jones, C. M. Arkadia enhances nodal-related signalling to induce mesendoderm. Nature 410: 830-834, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

109 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.